ABSTRACT
Background: In premedication, sedative premedication isgenerally directed before surgery. Premedication is theorganization of medication before anaesthesia. It is utilized toset up the patient for anaesthesia and to help give idealconditions to surgery. From numerous drugs midazolam hasbeen utilized broadly worldwide for pharmacologicalpremedication.Objective: The main goal of this study is to scrutinise theeffect of midazolam after premedication to reduce anxietyamong patients.Methods: The inclusion criteria of the study are the patientsunder 8 years of age scheduled for elective surgery ordiagnostic procedures requiring anaesthesia, and patients whoprescribed anxiolytic premedication with midazolam by theanaesthesiologist. At a local hospital named 250 Bed (MedicalCollege) Hospital located in Patuakhali, Bangladesh, aprospective descriptive observational study was conductedwith 100 paediatric patients scheduled for surgical ordiagnostic procedures needful of anaesthesia techniques. Thestudy duration was almost two years from the October 2016 toOctober 2018.Results: After numerous information and examinationinvestigation it was discovered that midazolam is exceptionallyviable drug for premedication with no symptom.
ABSTRACT
Objective To determine the total polyphenol content, antioxidant activity and antibacterial properties of the extracts of different Bangladeshi tea varieties such as flowery broken orange pekoe, broken orange pekoe, red dust and green tea. Methods Total phenolic and flavonoid contents were determined by Folin–Ciocalteu and aluminum chloride colorimetric assay, respectively. The antioxidant capacity was determined by ferric ion reducing antioxidant power and phosphomolybdenum method. Antibacterial activity was evaluated by disc diffusion method in agar plate and subsequently, the minimum inhibitory concentration was determined by broth dilution method. Results Total phenolic and flavonoid contents were significantly higher (P < 0.05) in green tea compared to other three black tea varieties. The green tea also showed a higher free radical scavenging and antioxidant activities than all the other tea varieties tested (P < 0.05). In addition, the extracts of all four tea varieties showed inhibitory activity against several pathogenic bacteria and also the same trend of higher antimicrobial activity of green tea than other tea varieties was observed. Conclusions Taken together, the results of this study demonstrated that Bangladeshi tea, especially the green tea, may act as a substitute for natural antioxidants and as a promising antibacterial agent for beneficial influence in human health.
ABSTRACT
In this study, we evaluated the protective effects of water Hyacinth Root Powder [HRP] on arsenic-mediated toxic effects in mice. Swiss albino mice, used in this study, were divided into four different groups [for each group n=5]. The control group was supplied with normal feed and water, Arsenic group [As-group] was supplied with normal feed plus arsenic [sodium arsenite]-containing water, and arsenic+hyacinth group [As+Hy group] was supplied with feed supplemented with HRP plus arsenic water. The remaining Hy-group was supplied with feed supplemented with HRP plus normal water. Oral administration of arsenic reduced the normal growth of the mice as evidenced by weight loss. Interestingly, tip of the tails of these mice developed wound that caused gradual reduction of the tail length. Supplementation of HRP in feed significantly prevented mice growth retardation and tail wounding in As+Hy group mice. However, the growth pattern in Hygroup mice was observed to be almost similar to that of the control group indicating that HRP itself has no toxic or negative effect in mice. Ingested arsenic also distorted the shape of the blood cells and elevated the serum enzymes such as lactate dehydrogenase [LDH], alkaline phosphatase [ALP] and serum glutamic pyruvic transaminase [SGPT]. Importantly, elevation of these enzymes and distortion of blood cell shape were partially reduced in mice belong to As+Hy group, indicating HRP-mediated reduction of arsenic toxicity. Therefore, the preventive effect of hyacinth root on arsenic-poisoned mice suggested the future application of hyacinth to reduce arsenic toxicity in animal and human